Febrero-Abril 2000 3
ISSN 1317-987X
 
Buscar




Artículos
 



Neurociencia
En búsqueda de un sitio de acción para el efecto central de los analgésicos no opioides

Referencias

  1. Carlsson K-H; Helmreich J; Jurna I. Activation of inhibition from the periaqueductal grey matter mediates central analgesic effect of metamizol (dipyrone). Pain 1986; 27:373-390.

  2. Ferreira SH. Prostaglandins, aspirin-like drugs and analgesia. Nature New Biol. 1972; 240:200-203.

  3. Ferreira SH. Prostaglandins: peripheral and central analgesia. Adv. Pain Res. Ther. 1983; 5:627-634.

  4. Ferreira SH; Lorenzetti BB; Correa FMA. Central and peripheral antialgesic action of aspirin-like drugs. Eur. J. Pharmacol. 1978; 53:39-48.

  5. Ferreira SH; Moncada S; Vane JR. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. Br. J. Pharmac. 1973; 49:86-97.

  6. Fields HL; Bry J; Hentall I; Zorman G. The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat. J. Neurosci. 1983; 3:2545-2552.

  7. Flower RJ; Vane JR. Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol (4-acetamidophenol). Nature (Lond. 1980, 1972:410-411.

  8. Handwerker HO; Beck A; Forster C; Gall T; Magerl W. Analgesic effects of dipyrone as compared to placebo: Birkhauser, 1990, pp19.

  9. He X; Neugebauer V; Schaible HG; Schmidt RF. New aspects of the mode of action of dypirone: Birkhauser, 1990. pp9.

  10. Lim RKS; Guzman F; Rodgers DW; Goto K; Braun C; Dickerson GD; Engle RJ. Site of action of narcotic and non-narcotic analgesics determined by blocking bradykinin-evoked visceral pain. Arch. Int. Pharmacodyn. 1964; 152:25-58.

  11. Moreau J-l; Schmitt P; Karli P. Morphine applied to the ventral tegmentum differentially affects centrally and peripherally induced aversive effects. Pharmacol. Biochem. Behav. 1985; 23:931-936.

  12. Ramwell PW; Shaw JE. Spontaneous and evoked release of prostaglandins from cerebral cortex of anethetized cats. Am. J. Physiol. 1966; 211:125-134.

  13. Taiwo YO; Levine JD. Protaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J. Neurosci. 1988; 8:1346-1349.

  14. Tortorici V; Vanegas H. Putative role of medullary off- and on-cells in the antinociception produced by dipyrone (metamizol) administered systemically or microinjected into PAG. Pain. 1994; 57:197-205.

  15. Tortorici V; Vanegas H. Antinociception induced by systemic or PAG-microinjected lysine-acetylasilicylate in rats. Effects on tail-flick related activity of medullary off- and on-cells. Eur. J. Neurosci. 1995; 7:1857-1865.

  16. Tortorici V; Robbins CS; Morgan MM. Tolerance to the antinociceptive effect of morphine microinjections into the ventral but not lateral-dorsal periaqueductal gray of the rat. Behav. Neurosci. 1999a; 113:833-839.

  17. Tortorici V; Rodríguez F; Vanegas H. Progressive decrease of the antinociceptive effect of dipyrone following repeated microinjection into the ventromedial PAG of the rat. Abstracts; 9th World Congress on Pain 1999b:23.

  18. Tortorici V; Vásquez E; Vanegas H. Naloxone partial reversal of the antinociception produced by dipyrone microinjected in the periaqueductal gray of rats. Possible involvement of medullary off- and on-cells. Brain Res. 1996; 725:106-110.

  19. Vanegas H; Barbaro NM; Fields HL. Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons. Brain Res. 1984a; 321:127-133.

  20. Vanegas H; Barbaro NM; Fields HL. Tail-flick related activity in medullospinal neurons. Brain Res. 1984b; 321:135-141.

  21. Vanegas H; Tortorici V; Eblén-Zajjur A; Vásquez E. PAG-microinjected dipyrone (metamizol) inhibits responses of spinal dorsal horn neurons to natural noxious stimulation in rats. Brain Res. 1997; 759:171-174.

  22. Vaughan CW; Ingram SL; Connor MA; Christie MJ. How opioids inhibit GABA-mediated neurotransmission. Nature (Lond.) 1997; 390:611-614.

  23. Yaksh TL. Central and peripheral mechanisms of the antialgesic action of acetylsalicylic acid: Raven, 1982. pp 137.

  24. Zimmermann M. Neurobiological concepts on pain; its assessment and therapy: Elsevier, 1984. p15.

Generalidades
Una visión diferente
El aporte de nuestro laboratorio
Lista de abreviaturas
Referencias

NOTA: Toda la información que se brinda en este artículo es de carácter investigativo y con fines académicos y de actualización para estudiantes y profesionales de la salud. En ningún caso es de carácter general ni sustituye el asesoramiento de un médico. Ante cualquier duda que pueda tener sobre su estado de salud, consulte con su médico o especialista.





Instituto de Medicina Tropical - Facultad de Medicina - Universidad Central de Venezuela.
Elaborado por el Centro de Análisis de Imágenes Biomédicas Computarizadas CAIBCO,
caibco@ucv.ve
Este portal ha sido desarrollado gracias al apoyo del Fonacit