Asociación Venezolana para el Avance de la Ciencia
Reposicionamiento de drogas-avances, alcances y oportunidadespara el descubrimiento de nuevos fármacos
Referencias
1. Romina Armando, Diego
Mengual, Daniel Gomez. New drugs are not enoughdrug repositioning in oncology:
An update. Int. J. Oncol. 56, 651-68 (2020).
2. Juan R. Rodrigues,
Jaime Charris, Rosa Ferrer, Neira Gamboa, Jorge Ángel, Bianca Nitzsche, Michael
Hoepfner, Michael Lein, Klaus Jung, Claudia Abramjuk. Effect of quinolinyl
acrylate derivatives on prostate cancer in vitro and in vivo. Invest. New
Drugs. 30, 1426-1433 (2012).
3. Jesús Romero, María
Acosta, Neira Gamboa, Michael Mijares, Juan De Sanctis, Jaime Charris.
Optimization of antimalarial, and anticancer activities of
(E)-methyl2-(7chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate. Bioorg.
Med. Chem. 26,815-823 (2018).
4. Miguel Rodríguez, Joyce
Gutiérrez, José Domínguez, Philippe Peixoto, Alexis Fernández, Noris Rodríguez,
Denis Deffieux, Luis Rojas, Stéphane Quideau, Laurent Pouységu, Jaime Charris.
Synthesis and leishmanicidal evaluation of sulfanyl and sulfonyl-tethered
functionalized benzoate derivatives featuring a nitroimidazole moiety. Arch.
Pharm. 353, e2000002 (2020).
5. Zuleima Blanco, Michael
R. Mijares, Hegira Ramírez, Esteban Fernandez‑Moreira, Henry J. Oviedo, Noris M.
Rodríguez, Jaime E. Charris. In vitro
evaluation and in vivo efficacy of nitroimidazole‑sulfanyl ethyl derivatives against
Leishmania (V.) braziliensis and Leishmania (L.) mexicana. Parasitol. Res. 120,
3307-3317 (2021).
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