Bioquímica cerebral 1H Magnetic Resonance Spectroscopy (MRS) assessment of the effects of Eicosapentaenoic-Docosahexaenoic Acids and Choline-Inositol supplementation on Children with Attention Deficit Hyperactivity Disorder (ADHD)
References
Hoffmann H.:
Der Struwwelpeter oder lustige Geschichten und drollige Bilder für Kinder
von 3 bis 6 Jahren. 588. Auflage; Originalausgabe von Verlag Rütten &
Löning, Frankfurt am Main. Bei Loewes Verlag Ferdinand Carl, Stuttgart
1934
Still
G. Some abnormal psychical conditions in children. Lancet. 1902;1:1008-1012,
1077-1082, 1163-1168.
Diagnostic
and Statistical Manual of Mental Disorders Text Revision (DSM-IV-TR). Diagnosis,
Etiology and Treatment 2004; Michael B. First (Editor), Allan Tasman (Editor)
Wiley, John & Sons Washington DC. American Psychiatric Association;
4th edition, June 2000
Swanson
JM, Sergeant JA, Taylor E, Sonuga-Barke EJ, Cantwell DP: Attention-deficit
hyperactivity disorder and hyperkinetic disorder. Lancet 1998; 351:429?433
Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Vaituzis AC, Dickstein DP,
Sarfatti SE, Vauss YC, Snell JW, Lange NL, Kaysen D, Krain AL, Ritchie GF,
Rajapakse JC, Rapoport JL:
Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity
disorder. Arch Gen Psychiatry 1996; 53:607?616
Filipek PA, Semrud-Clikeman M, Steingard RJ, Renshaw PF, Kennedy DN, Biederman
J:
Volumetric MRI analysis comparing subjects having attention-deficit hyperactivity
disorder and normal controls. Neurology 1996; 48:589?601
Casey BJ, Trainor R, Giedd J, Vauss Y, Vaituzis CK, Hamburger S, Kozuch P,
Rapoport JL:
The role of the anterior cingulote in automatic and controlled processes,
a developmental neuroanatomical study. Dev Psychobiol 1997; 30:61?69
Aylward EH, Reiss AL, Reader MJ, Singer HS, Brown JE, Denckla MB:
Basal ganglia volumes in children with attention deficit-hyperactivity disorder.
J Child Neurol 1996; 11:112?115
Hynd
GW, Semrud-Clikeman M, Lorys AR, Novey ES, Eliopulos D: Brain morphology
in developmental dyslexia and attention deficit disorder/hyperactivity. Arch
Neurol 1990; 47:919?922
Castellanos FX, Giedd JN, Berquin PC, Walter JM, Sharp W, Tran T, Vaituzis
AC, Blumenthal JD, Nelson J, Bastain TM, Zijdenbos A, Evans AC, Rapoport JL.
Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity
disorder. Arch Gen Psychiatry. 2001;58(3):289-95.
Castellanos F., Acosta M.
Neuroanatomía del trastorno por déficit de atención con
hiperactividad Rev. Neurol. 2004; 38 (Supl 1): S131-136
Durston S, Hulshoff Pol HE, Schnack HG, Buitelaar JK, Steenhuis MP, Minderaa
RB, Kahn RS, van Engeland H.
Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder
and their unaffected siblings. J Am Acad Child Adolesc Psychiatry. 2004;43(3):332-40.
Alvarado A y Hernández N.:
Fundamentos Bioquímicos y Aplicaciones de la Espectroscopía
de Hidrógeno por Resonancia Magnética. Rev. Fac. Med. 2000;
23 (Supl 1): 18-20,
Alvarado
A., Díaz, L., Itriago S., Sucre,Z., Mayobre,F. and Itriago P.:1H
Magnetic Resonance Spectroscopy (MRS) in Attention Déficit Hyperactivity
Disorder (ADHD). Radiology 1999; 213: 464.
Alvarado A, Zapata G, Díaz L, Sucre Z, Veracoechea G, Pérez
R, Hernández M and Itriago F.:
Proton Magnetic Resonance Spectroscopy and Electroencephalograpic Activity
in Attention Déficit Disorder. Vitae 2003;(15). http:// caibco.ucv.ve
/ vitae / vitaequince / artículos / bioquímicacerebral / archivos
Z. Jin, Y.F. Zang, Y.W. Zeng, L. Zhang, Y.F. Wang:
Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit
hyperactivity disorder: A 1H-Magnetic Resonance Spectroscopy study. Neuroscience
Letters 2001; 315: 45?48
Carrey N, MacMaster FP, Sparkes SJ, Khan SC, Kusumakar V.
Glutamatergic changes with treatment in attention deficit hyperactivity disorder:
a preliminary case series. J Child Adolesc Psychopharmacol 2002;12(4):331-6
Carrey N, MacMaster FP, Fogel J, Sparkes S, Waschbusch D, Sullivan S, Schmidt
M.
Metabolite changes resulting from treatment in children with ADHD: A 1H-MRS
study. Clin Neuropharmacol. 2003; 26(4): 218-21.
MacMaster FP, Carrey N, Sparkes S, Kusumakar V.
Proton spectroscopy in medication-free pediatric attention-deficit/hyperactivity
disorder. Biol Psychiatry. 2003; 53(2):184-7.
Courvoisie H, Hooper SR, Fine C, Kwock L, Castillo M.
Neurometabolic functioning and neuropsychological correlates in children with
ADHD-H: preliminary findings. J Neuropsychiatry Clin Neurosci. 2004; 16(1):63-9.
Yeo
RA, Hill DE, Campbell RA, Vigil J, Petropoulos H, Hart B, Zamora L, Brooks
WM.: Proton magnetic resonance spectroscopy investigation of the
right frontal lobe in children with attention-deficit/hyperactivity disorder.
J Am Acad Child Adolesc Psychiatry.2003;42(3):303-10
Chandan J. Vaidya , Austin G, Kirkorian G, Ridlehuber H, Desmond J,. Glover
G and Gabrieli J.
Selective effects of methylphenidate in attention deficit hyperactivity disorder:
A functional magnetic resonance study. PNAS 1998; 95( 24): 14494-14499
Rubia K, Overmeyer S, Taylor E, Brammer M, Williams S, Simmons A, and Bullmore
E.
Hypofrontality in Attention Deficit Hyperactivity Disorder During Higher-Order
Motor Control: A Study With Functional MRI. Am J Psychiatry 1999; 156:891?896
Anderson CM, Polcari A, Lowen SB, Renshaw PF, Teicher MH.
Effects of methylphenidate on functional magnetic resonance relaxometry of
the cerebellar vermis in boys with ADHD. Am J Psychiatry. 2002 ;159(8):1322-8.
Zametkin A, Nordahl T, Gross M, King A, Semple W, Rumsey J, Hamburger S ,
Cohen R.:
Cerebral glucose metabolism in adults with hyperactivity of childhood onset.
N. Eng. J Med. 1990; 323(15):1361-1366
Bekaroglu
M, Aslan Y, Gedik Y. Relationships between serum free fatty acids
and zinc, and attention deficit hyperactivity disorder: a research note. J
Child Psychol Psychiatry. 1996;37(2):225-7
Bekaroglu M, Aslan Y, Gedik Y, et al. Relationships
between serum free fatty acids and zinc, and attention deficit hyperactivity
disorder: a research note. J Child Psychol Psychiatry 1996;37:225-227.
Gibson RA. The
effect of dietary supplementation with evening primrose oil on hyperkinetic
children. Proc Nutr Soc Aust 1985; 10:196-199.
Aman MG, Mitchell EA, Turbott SH.
The effects of essential fatty acid supplementation by Efamol in hyperactive
children. J Abnorm Child Psychol. 1987;15(1):75-90
Richardson, A.J., Puri, B.K.
A randomized double-blind, placebo-controlled study of the effects of supplementation
with highly unsaturated fatty acids on ADHD-related symptoms in children with
specific learning difficulties. Prog. Neuropsychopharmacol. Biol. Psychiatry
2002; 26(2): 233-9.
Kalmijn, S., et al. Dietary
fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol
1997; 42(5): 776-82
Hamazaki
T, Sawazaki S, Itomural M, Asaoka E, Nagao Y, Nishimura N, Yazawa K, Kuwamori
T, Kobayashi M. The effect of docosahexaenoic acid on aggression in young
adults. A placebo-controlled double-blind study. J Clin Invest 1975;97(4):1129-33.
Mitchell EA, Lewis S, Cutler DR.
Essential fatty acids and maladjusted behavior in children. Prostaglandins
Leukot Med 1983;12(3):281-7.
Richardson,
A.J., Puri, B.K. The potential role of fatty acids in attention-deficit/hyperactivity
disorder. Prostaglandins Leukot. Essent. Fatty Acids 2000;63(1-2): 79-87.
Richardson, A.J., Puri, B.K.
A randomized double-blind, placebo-controlled study of the effects of supplementation
with highly unsaturated fatty acids on ADHD-related symptoms in children with
specific learning difficulties. Prog. Neuropsychopharmacol. Biol. Psychiatry
2002; 26(2): 233-9.
Richardson,
A.J., Ross, M.A. Fatty acid metabolism in neurodevelopmental disorder:
a new perspective on associations between attention-deficit/hyperactivity
disorder, dyslexia, dyspraxia and the autistic spectrum. Prostaglandins Leukot.
Essent. Fatty Acids 2000; 63(1-2): 1-9.
Jorisse, B.L., Brouns, F., Van Boxtel, M.P., Ponds, R.W., Verhey, F.R., Jolles,
J., Riedel, W.J.
The influence of soy-derived phosphatidylserine on cognition in age-associated
memory impairment. Nutr. Neurosci. 2001; 4(2): 121-34.
Yeo
RA, Hill D, Campbell R, Vigil J, Brooks WM.
Developmental instability and working memory ability in children: a magnetic
resonance spectroscopy investigation. Dev Neuropsychol. 2000;17(2):143-59.
Jimenez JV, Richards TL, Heide AC, Grierson JR, Shankland EG.
Incorporation of a phosphonium analogue of choline into the rat brain as measured
by magnetic resonance spectroscopy. Magn Reson Med. 1995;33(3):285-92.
Stoll
AL, Renshaw PF, De Micheli E, Wurtman R, Pillay SS, Cohen BM. Choline
ingestion increases the resonance of choline-containing compounds in human
brain: an in vivo proton magnetic resonance study. Biol Psychiatry. 1995;37(3):170-174.
Babb
SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, Renshaw
PF. Chronic citicoline increases phosphodiesters in the brains of
healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy
study. Psychopharmacology 2002 ;161(3):248-54
Babb SM, Ke Y, Lange N, Kaufman MJ, Renshaw.
Oral choline increases choline metabolites in human brain. Psychiatry Res.
2004;130(1):1-9.
Babb SM, Appelmans KE, Renshaw PF, Wurtman RJ, Cohen BM. Differential
effect of CDP-choline on brain cytosolic choline levels in younger and older
subjects as measured by proton magnetic resonance spectroscopy. Psychopharmacology
1996;127(2):88-94.
Tan J, Bluml S, Hoang T, Dubowitz D, Mevenkamp G, Ross B.
Lack of effect of oral choline supplement on the concentrations of choline
metabolites in human brain. Magn Reson Med. 1998;39(6):1005-10.
Miller BL, Chang L, Booth R, Ernst T, Cornford M, Nikas D, McBride D, Jenden
DJ.
In vivo 1H MRS choline: correlation with in vitro chemistry/histology. Life
Sci. 1996;58(22):1929-35.
Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SM.
Decreased brain choline uptake in older adults. An in vivo proton magnetic
resonance spectroscopy study. JAMA. 1995;274(11):902-7.
Kato
T, Hamakawa H, Shioiri T, Murashita J, Takahashi Y, Takahashi S, Inubushi
T. Choline-containing compounds detected by proton magnetic resonance
spectroscopy in the basal ganglia in bipolar disorder. J Psychiatry Neurosci.
1996;21(4):248-54.
Aman MG, Mitchell EA, Turbott SH.
The effects of essential fatty acid supplementation by Efamol in hyperactive
children. J Abnorm Child Psychol 1987; 15: 75-90.
Arnold LE, Kleykamp D, Votolato NA, Taylor WA, Kontras SB, Tobin K.
Gamma-linolenic acid for attention-deficit hyperactivity disorder: placebo-controlled
comparison to D-amphetamine. Biol Psychiatry 1989; 25: 222-228.
Arnold LE, Kleykamp D, Votolato NA, Gibson RA, Horrocks L.
Potential link between dietary intake of fatty acids and behavior: pilot exploration
of serum lipids in ADHD. J Child Adolesc Psychopharmacol 1994; 4: 171-180.
Bourre J-M, Bonneil M, Clement M, et al.
Function of dietary polyunsaturated fatty acids in the nervous system. Prostaglandins
Leukotr Essent Fatty Acids 1993; 48: 5-15.
Bourre J-M, Durand G, Pascal G, Youyou A.
Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by
alteration of dietary fat. J Nutr 1988; 119: 15-22.
Burgess
JR. Attention deficit hyperactivity disorder: observational and interventional
studies. NIH workshop on omega-3 essential fatty acids and psychiatric disorders.
National Institutes of Health: Bethesda, 1998, Sept. 2-3.
Burgess
JR, Stevens L, Zhang W, Peck L. Long-chain polyunsaturated fatty
acids in children with attention-deficit hyperactivity disorder. Am J Clin
Nutr 2000; 71: 327-330.
Stoll AL, Sachs GS, Cohen BM.
Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical
findings in lithium-treated patients. Biol Psychiatry 1996; 40(5):382-388.
Benjamin J, Agam G, Levine J, et al.
Inositol treatment in psychiatry. Psychopharmacol Bull 1995;31(1): 167?175.
Benjamin
J, Levine J, Fux M, et al. Double-blind, placebo-controlled, crossover
trial of Inositol treatment for panic disorder. Am J Psychiatry 1995;152:
1084?1086.
Levine
J, Barak Y, Kofman O, and Belmaker RH. Follow-up and relapse analysis
of an Inositol study of depression. Isr J Psychiatry Relat Sci 1995;32(1):
14?21.
Levine J.
Controlled trials of Inositol in psychiatry. Eur Neuropsychopharmacol 1997;7:147?155.
Einat
H, Belmaker RH. The
effects of Inositol treatment in animal models of psychiatric disorders J
Affect Disord. 2001; 62(1-2):113-21.
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