Bioanálisis Asociación de la hormona estimulante de tiroides, tiroxina y triyodotironina con los metales pesados plomo y mercurio enpacientes con posible hipertiroidismo
Results
Sociodemographic
Aspects and TSH, T3F and T4F Level
When TSH and T3F levels were associated with Pb
and Hg concentration, it was found that there is a significant negative
association for TSH (r=0.997 and r= 0.993), while for T3F there is a tendency
to increase the levels of this hormone as the concentration of Pb Hg increases
(r=0.997 and 0.976). The above is shown in Figures 1a-b and 2a-b.
Table 1. Levels of TSH (µUI/L) T3F (pg/mL) and T4F (ng/mL) in both groups
Lead
and mercury levels in both groups
With respect to the analysis of Pb in whole blood and
Hg in partial urine, it was found that the study group presented values above
the biological exposure index or permissible limit (BEIs)established byAmerican
Conference of Governmental Industrial Hygienists Biological (ACGIH, 2015), with
Pb values up to 8 µg/dL for
non-occupationally exposed women and Hg values up to 5 µg/g creatinine. Other data of interest are shown in Table 2.
Table2. Concentration of lead (µg/dL) and mercury
(µg/g of creatinine)
TSH
and T3F levels were associated with Pb and Hg concentration
When TSH and T3F levels were associated with Pb and Hg
concentration, it was found that there is a significant negative association
for TSH (r=0.997 and r= 0.993), while for T3F there is a tendency to increase
the levels of this hormone as the concentration of Pb Hg increases (r=0.997 and
0.976). The above is shown in Figures 1a-b and 2a-b.
Figure 1. Relationship of TSH levels with
heavy metal concentrations in blood and urine of the study group
Figure 2. Relationshipof T3F levels with heavy metal concentrations
in blood and urine of the study group.
NOTA:Toda la información que se brinda en este artículo es de carácter investigativo y con fines académicos y de actualización para estudiantes y profesionales de la salud. En ningún caso es de carácter general ni sustituye el asesoramiento de un médico. Ante cualquier duda que pueda tener sobre su estado de salud, consulte con su médico o especialista.
Instituto de Medicina Tropical - Facultad de Medicina - Universidad Central de Venezuela.
Elaborado por el Centro de Análisis de Imágenes Biomédicas Computarizadas CAIBCO, caibco@ucv.ve
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