Gliomatosis Cerebri (GC) was first reported in 1938 by Nevin who described a diffuse overgrowth of neuroglial cells in wide areas of the brain (1). Magnetic Resonance Imaging (MRI) usually shows a diffuse signal intensity abnormality due to the infiltrative process without mass effect, absence of necrosis and lack of contrast enhancement (2). Therefore, MRI findings are not specific and the use of ¹H Magnetic Resonance Spectroscopy (MRS) to diagnose and characterize GC has been proposed (3). The purpose of this work was to identify the metabolic profiles in a case of GC using MRS.