Obesity a predictor of outcomes of COVID‐19 hospitalized patients—A systematic review and meta‐analysis
Fecha de recepción: 30/08/2020
Fecha de aceptación:
23/09/2020
Abstract
Coronavirus disease 2019 (COVID‐19) pandemic is a global health crisis. Very few
studies have reported association between obesity and severity of COVID‐19. In
this meta‐analysis, we assessed the association of obesity and outcomes in COVID‐
19 hospitalized patients. Data from observational studies describing the obesity or
body mass index and outcomes of COVID‐19 hospitalized patients from December
1, 2019, to August 15, 2020, was extracted following PRISMA guidelines with a
consensus of two independent reviewers. Adverse outcomes defined as intensive
care units, oxygen saturation less than 90%, invasive mechanical ventilation, severe
disease, and in‐hospital mortality. The odds ratio (OR) and 95% confidence interval
(95% CI) were obtained and forest plots were created using random‐effects models.
A total of 10 studies with 10,233 confirmed COVID‐19 patients were included. The
overall prevalence of obesity in our study was 33.9% (3473/10,233). In metaanalysis,
COVID‐19 patient with obesity had higher odds of poor outcomes compared
with better outcomes with a pooled OR of 1.88 (95% CI: 1.25–2.80;
p = 0.002), with 86% heterogeneity between studies (p < 0.00001). Our study suggests
a significant association between obesity and COVID‐19 severity and poor
outcomes. Our results findings may have important suggestions for the clinical
management and future research of obesity and COVID‐19.
Key Word
2019‐nCoV, body mass index (BMI), coronavirus disease, COVID‐19, mechanical ventilation, mortality, obesity, SARS‐CoV‐2, severe acute respiratory syndrome
Obesity a predictor of outcomes of COVID‐19 hospitalized patients—A systematic review and meta‐analysis
Preeti Malik MD, MPH1 | Urvish Patel MD, MPH1 | Karan Patel BS2 | Mehwish Martin MBBS3 | Chail Shah MBBS4 | Deep Mehta MD, MSCR5 |
Faizan Ahmad Malik MD6 | Ashish Sharma MD, FACP 1Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, USA
2MS(1), Cooper Medical School of Rowan University, New Jersey, USA
3Department of Internal Medicine, Baylor St. Luke's Medical Center, Houston, Texas, USA
4Department of Internal Medicine, Brooklyn Cancer Care, New York, New York, USA
5Department of Clinical Research Program, Icahn School of Medicine at Mount Sinai, New York, USA
6Department of Internal Medicine, Texas Tech University Health Sciences Center, Odessa, Texas, USA
7Department of Internal Medicine, Yuma Regional Medicine, Yuma, Arizona, USA
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