Table 1.- Metabolite ratios obtained in GC at four different brain locations. An increase in the mI/Cr, Cho/Cr and Cho/NAA ratios was observed within brain areas affected by GC in comparison with unaffected areas. + signus denotes the detection of signals for Lip and Lac.

The different spectroscopic patterns obtained in the GC case are illustrated in Figures 2, 3 , 4 and 5.

Figure 2. Spectroscopic pattern obtained from 2D Multivoxel in a projection located at the Brain Interhemispheric line.

Figure 2 shows a spectroscopic pattern in which the most prominent intensity signal is represented by the mI pick. The intensity signals for Cho, Cr and NAA are disposed as in another Brain Tumors: Increase in the Cho/Cr ratio, decrease of the NAA/Cr ratio. Signals for Lac and Lip were also observed. MRS performed at long echo time (Te=135 ms) confirms Lac peak as an inverted doublet signal (Data not shown).

Figure 3. This spectra shows a different pattern observed at the right Brain Hemisphere.

Figure 3 shows similar spectroscopic profile compared to Figure 2 with an important difference observed in the NAA intensity signal. According with this pattern the gliosis is more evident in voxels located between the two Hemispheres than voxels placed at Right or Left sides of the Brain.

Figure 4. The MRS demonstrate the pattern observed at the left Brain Hemisphere.

Figure 4 shows a robust signal intensity for mI with high peaks for Cho and Cr in this GC case.

Figure 5. Reference pattern obtained at unaffected Left Brain Hemisphere.

Figure 5 is extracted from a voxel placed on the left side of the brain in apparently unaffected tissue. We clearly note the expected values for NAA/Cr, Cho/Cr and Cho/NAA ratios. Therefore, the intensity signal of mI peak is higher than Cho suggesting that probably some osmolar changes occurred as an effect of the proximity of the affected tissue.