Octubre-Diciembre 2003 17
ISSN 1317-987X
 
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Anatomía Patológica
Inmunohistoquímica en tumores de partes blandas

Referencias

  1. Fletcher CDM. The use of immunohistochemistry in the diagnosis of soft tissue tumours. Histopathology 1986, 10:771-773.
  2. Ordoñez NG. Application of immunohistochemistry in the diagnosis of soft tissue sarcomas: a review and update. Adv Anat Pathol 1998, 5:67-85.
  3. Suster S. Recent advances in the application of immunohistochemical markers for the diagnosis of soft tissue tumors. Diagn Pathol 2000, 17: 225-235.
  4. García Tamayo J, Henández C. Diagnóstico Inmunohistoquímico de los Tumores Malignos de Células Redondas. Vitae: Academia Médica Digital 2002, 10: http://caibco.ucv.ve/Vitae/VitaeDiez/Articulos/Anatomia/ArchivosHTML/Introduccion.htm
  5. Guillou L, Coindre J, Gallager G y col. Detection of synovial sarcoma translocation t(x ;18)(SYT ;SSX) in parafin-embedded tissues using reverse transcriptase-polymerase chain reaction : a reliable and powerful diagnostic tool for pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives. Human Pathol 2001, 32:101-112.
  6. Miettinen M,Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch FF. Epithelioid sarcoma: an immunohistochemical analysisi of 112 classical and variant cases and a discussion of the differential diagnosis. Hum Pathol 1999, 30:934-942.
  7. García Tamayo J, Picott E, Henández C, León Z. Estudio histológico e inmunohistoquímico en 120 casos de linfomas de linfocitos T. Vitae: Academia Médica Digital 2002, 12: http://caibco.ucv.ve/Vitae/VitaeDoce/Articulos/Anatomia/ArchivosHTML/Introduccion.htm
  8. Piris M, Brown DC, Gatter K, Mason DY. CD30 expression in non-Hodgkin´s lymphoma. Histopathology 1990,17:211-218.
  9. García Tamayo J, Hernández C. Aplicación del anticuerpo CD34 en el diagnóstico de los tumores fusocelulares. Vitae: Academia Médica Digital 2002, 11: http://caibco.ucv.ve/Vitae/VitaeOnce/Articulos/Anatomia/ArchivosHTML/Introduccion.htm
  10. Suster S, Fisher C, Moran C. Expression of bcl 2 Oncoprotein in benign and malignant Spindle Cell Tumors of Soft Tissue, skin, serosal surfaces and gastrointestinal tract. Am J Surg Pathol 1998, 22:863-872.
  11. Applemman H, Helwig EB. Gastric epithelioid leiomyoma and leiomyosarcoma (leiomyoblastoma). Cancer 1976, 38: 708-728.
  12. Salazar H, Totem RS. Leiomyoblastoma of the stomach. An ultrastructural study. Cancer 1970, 25: 176-185.
  13. Miettinen M. Gastrointestinal stromal tumors. An immunohistochemical study of cellular differentiation. Am J Clin Pathol 1988; 98: 601 -610.
  14. Herrera G, Cerezo L, Jones JE. Gastrointestinal autonomic nerve tumors."Plexosarcomas". Arch Pathol Lab Med 1989, 27: 275-284.
  15. Appleman H. Smooth muscle tumors of the gastrointestinal tract. What we know now that Stout did´nt know. Am J Surg Pathol 1896, 10: 83-89.
  16. Walker P, Dvorak M. Gastrointestinal autonomic nerve (GAN) tumor. Ultrastructural evidence of a newly recognized entity. Arch Pathol Lab Med 1986, 110: 309-316.
  17. Chan JK. Mesenchymal tumours of the gastrointestinal tract: a paradise for acronyms (STUMP, GIST, GANT, and now GIPACT), implication of c-kit in the genesis, and yet another of the many emerging roles of the interstitial cell of Cajal in the pathogenesis of gastrointestinal diseases? Adv Anat Pathol 2002, 9:19-40.
  18. Miettinne M, Majidi M, Lasota J. Pathology and diagnostic criteria of Gastrointestinal Stromal Tumors (GIST): a review. Europ J of Cancer 2002, 38:Suppl 5, S37-S51.
  19. Joensuu H, Roberts PJ, Sarlomo-Rikala M y col. Effect of tiroxina kinase inhibitor STI571 in a patient with metastatic gastrointestinal stromal tumor. New Engl J Med 2001, 344:1052-1056.
  20. O´Leary T, Ernst S, Przygodzki R, Emory T, Sobin LH. Loss of heterozygocity at 1p36 predicts poor prognosis in gastrointestinal stromal / smooth muscle tumors. Lab Invest 1999, 79:1461-1467.
  21. Debiec-Rychter M, Sciot R, Pauwels P, Schoemakers E, Dal Cin P, Hagemeijer A. Molecular cytogenetic definition of three distinct chromosome arm 14q deletion intervals in gastrointestinal stromal tumors. Genes Chromosom Cancer 2001, 32:26-32.
  22. Miettinen M, Sobin LH, Sarlomo-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with referente to CD117(KIT). Mod Pathol 2000, 13:1134-1142.
  23. Watanabe K, Kusakabe T, Hoshi N, Sato A, Susuki T. H Caldesmon in leiomyosarcoma and tumors of smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor. Human Pathol 1999, 30:392-396.
  24. Watanabe K, Tajino T, Sekiguchi M,Susuki T. H Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors. Am J Clin Pathol 2000, 113:663-668.
  25. Hisaoka M, Wei-Qi S, Jiam W, Morio T, Hashimoto H. Specific but variable expression of h-Caldesmon in leiomiosarcomas: an immunohistochemical reassessment of a novel myogenic maker. Appl Immunohistochem Mol Morph 2001, 9:302-308.
  26. Miettinen MM, Sarlomo-Rikala M, Kovatich AJ, Lasota J. Calponin and h-caldesmon in soft tissue tumors: consistent h-caldesmon immunoreactivity in gastrointestinal stromal tumors indicates traits of smooth muscle differentiation. Mod Pathol 1999, 12: 756-762.
  27. Dias P, Parhem DM, Shapiro DN, Webber BL, Hougton PJ. Myogenic regulatory protein ( MyoD1 ) expression in childhood solid tumors: diagnostic utility in rhabdomyosarcoma. Am J Pathol 1990, 137: 1283-1291.
  28. Coindre JM, de Mascarel A, De Trojani MMI, Pages A. Immunohistochemical study of rhabdomyosarcoma. Unexpected staining with S100 protein and cytoqueratin. J Pathol 1988, 155:127-132.
  29. Weintraub H, Davis R Tapscott S y col. The myoD gene family: nodal point during specificaction of the muscle cell linage. Science 1991, 251:761-766.
  30. Dias P, Chen B, Dilday B y col. Strong immunostaining for myogenin in rhabdomyosarcoma is significantly associated with tumors of the alveolar subclass. Am J Pathol 2000, 156:399-408.
  31. Downing JR, Khandekar A, Schurtleff SA y col. Multiple RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing´s sarcoma. Am J Pathol 1995, 146:626-634.
  32. Stout AP. A tumor of the ulnar nerve. Proc NY Pathol Soc 1918, 12:2-12.
  33. Ewing J. Diffuse endothelioma of bone. Proc NY Pathol Soc 1921, 21:17-24.
  34. Gledhill T, Garrido L, Caleiras E, Parada D, García Tamayo J. Tumor de Askin; estudio inmunohistoquímico y ultraestructural de dos casos. Patología (Mex) 1999, 36:135-139.
  35. Ambros I, Ambros P, Strehl S, y col. MIC 2 is a specific marker for Ewing´s sarcoma and peripheeral primitive neuroectodermal tumors. Cancer 1991, 67:1886-1893.
  36. Renshaw AA. 013 (CD99) in spindle cell tumor. Reactivity with hemangiopericytoma, solitary fibrous tumor, synovial sarcoma and meningioma but rarely with sarcomatoid mesothelioma. Appl Immunohistochem 1995, 3:250-256.
  37. Aurias A, Rimbaut C, Buffe D y col. Chromosomal translocations in Ewing´s sarcoma. New Engl J Med 1983, 309:496-497.
  38. Whang-Peng J, Triche TJ, Knutsen T y col. Chromosome translocation in peripheral neuroepithelioma. New Engl J Med 1984, 311:584-585.
  39. Zucman J, Delattre O, Desmaze C y col. Cloning and characterization of Ewing´s sarcoma and peripheral neuropeithelioma t (11;22) translocation breakpoints. Genes Chromosom Cancer 1992, 5: 271-277.
  40. Folpe AL, Hill CE, Parham DM, o´Shea PA, Weiss SW. Immunohistochemical detection of FLI-1 protein expresion: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing´s sarcoma/primitive neuroectodermal tumor. Am J Surg Pathol 2000, 24:16571662.
  41. Folpe AL, Chand EM, Goldblum JR, Weiss SW. Expression of Fli-1, a nuclear transcription factor, distinghishes vascular neoplasms from potential mimics. Am J Surg Pathol 2001, 25:1061-1066.
  42. Shanfeld RL, Edelman J, Willis JE, Tuason L, Goldblum JR. Immunohistochemical analysis of neural markers in peripheral primitive neuroectodermal tumors (pPNET) without light microscopic evidence of neural differentiation. Appl Immunohistochem1997, 5:78-86.
  43. Gu M, Antonescu CR, Guiter G, Huvos AG, Ladanyi M, Zakowoski MF. Cytokeratin immunoreactivity in Ewing´s sarcoma: prevalence in 50 cases confirmed by molecular diagnostic studies. Am J Surg Pathol 2000, 24:410-416.
  44. Hoerl HD, Goldblum JR. Immunoreactivity patterns of CD31 and CD68 in 28 cases of Kaposi´s sarcoma: evidence supporting endothelial differentiation in the spindle cell component. Appl Immunohistochem 1997, 5:173-178.
  45. Folpe AL, Veikkola T, Valtola R, Weiss SW. Vascular Endotelial Growth Factor Receptor -3 (VEGFR-3 ): A marker of vascular tumors with presumed lymphatic differentiation, including Kaposi´s sarcoma, Kaposiform and Dabska-type Hemangioendotheliomas and a subset of angiosarcomas. Mod Pathol 2000, 13:180-185.
  46. Jussila L, Valtola R, Partanen TA, Salven P, Heikkila P, Matikainen MT y col. Lymphatic endothelium and Kaposi´s sarcoma spindle cell detected bay antibodies against the vascular endothelial growth factor receptor-3. Cancer Res 1998, 58:1599-1604.
  47. Coindre JM. Immunohistochemistry in the diagnosis of soft tissue tumors. Histopathology 2003, 43:1-16.
  48. Brunnemann RB, Ro JY, Ordoñez NG, Mooney J, el Naggar AK, Ayala AG. Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 1999, 12:1034-1042.
  49. Hasegawa T, Matsuno Y, Shimoda T, Hasegawa F, Sano T, Hirohashi S. Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior. Hum Pathol 1999, 30:1464-1473.
  50. Pezella F, Tse AGD, Cordell JL, Pulford KAF, Gatter K, Mason DY. Expression of the bcl 2 protein is not specific for the 14;18 chromosomal translocation. Am J Pathol 1990, 137: 225-232.
  51. Enzinger FM. Epithelioid sarcoma. A sarcoma simulating a granuloma or a carcinoma. Cancer 10970, 26:1029-1041.
  52. Chase DR, Enzinger FM. Epithelioid sarcoma. Diagnosis, prognostic indicators and treatment. Am J Surg Pathol 1985, 9:241-263.
  53. Matsuzaki F, Mege RM, Jaffe SH y col. cDNAs of cell adhesion molecules of different specificity induce changes in cell sfhape and brder formation in cultured S 180 cells. J Cell Biol 1990, 110:1239-1252.
  54. Ashton-Key M, Cowley GP, Smith MEF. Cadherines in reactive lymph nodes and lymphomas: high expression in anaplastic large cell lymphomas. Histopathology 1996, 28:55-59.
  55. Smith MEF, Brown JI, Fisher C. Epithelioid sarcoma: presence of vascular-endothelial cadherin and lack of epithelial cadherin. Histopathology 1998, 33:425-431.
  56. Miettinen M, Fanburg-Smith JC, Virolainen M y col. Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis. Hum Pathol 1999, 30:934-942.
  57. Billings SD, Folpe AL, Weiss SW. Epithelioid sarcoma-like Hemangioendothelioma. Am J Surg Pathol 2003, 27:48-57.
  58. Weiss SW, Langloss JM, Enzinger FM. Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Lab Invest 1983, 49:299-308.
  59. Wick MR, Swanson PE, Scheitehauer BW, Manivel JC. Malignant peripheral nerve sheath tumor. An immunohistochemical study of 62 cases. Am J Clin Pathol 1987, 87:425-433.
  60. Laskin WB, Weiss SW, Bratthauer GL. Epithelioid variant of malignant peripheral nerve sheath cell tumor ( malignant epithelioid schwannoma). Am J Surg Pathol 1991, 15:1136-1145.
  61. Gerdes J, Li L, Schulter C. Immunochemical and molecular biological characterization of the cell proliferation associated nuclear antigen that is defined by the monoclonal antibody Ki67. Am J Pathol 1991, 138:867-873.
  62. Kindblom LG, Ahlden M, Meis-Kindblom JM, Stenman G. Immunohistochemical and molecular abalysis of p53, MDM2, proliferating cell nuclear antigen Ki67 in benign and malignant peripheral nerve sheath tumours. Virchows Arch 1995, 427:19-26.
  63. Watanabe T, Oda Y, Kinukawa N, Masuda K, Tsuneyoshi M. Malignant peripheral nerve sheath tumours: high Ki67 labelling index is the significant prognostic indicator. Histopathology 2001, 39:187-197.
Introducción
Materiales y métodos
Resultados: Caso NP 1011-2000 tumoración abdominal de un mes de evolución
Caso NP 487 ? 2000: tumor en parrilla costal derecha
Caso NP 959-2000: tumor toráxico izquierdo
Caso NP 233-2003: Lesión supraglótica
Caso NP 173-2003: tumoración en el cuello que compromete la glándula tiroides
Caso NP 920-2003: múltiples lesiones nodulares en miembros inferiores
Caso NP 920-2003 (Continuación)
Caso NP 1000-2000: tumor de células fusiformes en la región cervical
Caso NP 904-2000: de partes blandas en el muslo derecho
Caso NP 469-2003: tumor gástrico
Discusión
Referencias

NOTA: Toda la información que se brinda en este artículo es de carácter investigativo y con fines académicos y de actualización para estudiantes y profesionales de la salud. En ningún caso es de carácter general ni sustituye el asesoramiento de un médico. Ante cualquier duda que pueda tener sobre su estado de salud, consulte con su médico o especialista.





Instituto de Medicina Tropical - Facultad de Medicina - Universidad Central de Venezuela.
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