The
authors are not aware of any affiliations, memberships, funding, or financial
holdings that might be perceived as affecting the objectivity of this review.
Authors’ contributions
C.A.F.A.,
M.J.A., I.L.B and R.F.R. participated in selection and reviewing of cited
literature. C.A.F.A. aimed and wrote the preliminary version of this manuscript,
designed tables, performed art-work of figures, and performed the in silico analysis for miRNA target and
RNA hybridization prediction. F.A.P.U. did the staining technique for figure 1.
C.A.F.A., R.F.R., and F.A.P.U. implemented cell culture techniques for figure
3. C.A.F.A, R.F.R, F.A.P.U, R.G.A, M.J.A, I.L.B read, drafted, discussed and
approved the final version of this manuscript.
Acknowledgments
Research related to airway smooth muscle biology
is supported by grants from the CDCH-UCV,
(PG.09-8629.2013). C.A.F.A. and R.F.R.
thank to sección de biomembranas for supporting the press release of this
thesis. C.A.F.A thanks to Anthony J. Febres-Aldana for assisting in database
manipulation and critical review.