Abril - Junio 2007 31
ISSN 1317-987X
 
Buscar




Artículos
 




Virología
Mecanismos de acción de compuestos antivirales aislados en plantas: el Virus de la Inmunodeficiencia Humana como modelo.

Referencias

  1. Althaus, F. Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair. J. Cell Sci. 1992. 102: 663-670.
  2. Ambion, the RNA company. Protocol for trichloroacetic acid (TCA) precipitation. Disponible en: http://www.ambion.com/techlib/misc/tcapptn.html 
  3. Buckheit R. W., V. Fliakas-Boltz, W. D. Decker, J. L. Robertson, T. L. Stup, C. A. Pyle, E. L. White, J. B. McMahon, M. J. Currens, M. R. Boyd y J. P. Bader. Comparative anti-HIV evaluation of diverse HIV-l-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups. Antiviral Res. 1995. 26: 117-132.
  4. Buckheit R. W., E. L. White, V. Fliakas-Boltz, J. Russell, T. L. Stup, T. L. Kinjerski, M. C. Osterling, A. Weigand y J. P. Bader. Unique anti-Human Immunodeficiency Virus activities of the nonnucleoside Reverse Transcriptase inhibitors Calanolide A, Costatolide, and Dihydrocostatolide. Antimicrob. Agents Chemother. 1999. 43: 1827-1834.
  5. Cann, A. J. Principles of Molecular Virology. Third Edition. United Kingdom: Academic Press; 2001.
  6. Chivian M.D. Biodiversity: its importance for huma health. Interim executive summary. Center for Health and the Global Environment, Harvard Medical School. USA. 2003. Disponible en: http://chge.med.harvard.edu/publications/documents/Biodiversity_v2_screen.pdf>
  7. Coffin, J.M. Retroviridae: The viruses an their replication. En: Virology (eds. B.N. Fields, D.M. Knipe & P.M. Howley), Vol. Two. USA: Lippincott-Raven Publishers; 1996.
  8. Cos, P., L. Maes., D. Vanden Berghe., N. Hermans., L. Pieters y A. Vlietinck. Plant substances as anti-HIV agents selected according to their putative mechanism of action. J. Nat. Prod. 2004. 67: 284-293.
  9. Duke, N. C. Rhizophora apiculata, R. mucronata, R. stylosa, R .x annamala, R. x lamarckii (Indo-West Pacific Stilt Mangroves). Species profiles for Pacific island agroforestry. Ver. 1.1. 2005. Disponible en: www.traditionaltree.org 
  10. Esparza, J. The global VIH vaccine enterprise. Int. Microb. 2005. 8: 93-101. 
  11. Geleziunas R. y W. C. Greene. Molecular insights into HIV-1 infection and patogenesis. En: The medical management of AIDS. (eds. M. A. Sande y P. A. Volderbing). USA: W.B. Saunders Company; 2000.
  12. Hirsch, M. S. y J. Curran. Human Immunodeficiency Viruses. En: Virology (eds. B.N. Fields, D.M. Knipe & P.M. Howley), Vol. Two. USA: Lippincott-Raven Publishers. 1996.
  13. Hruby, D. E. Vaccinia virus vectors: New Strategies for producing recombinant vaccines. Clin. Microbiol. Rev. 1990. 3: 153-170.
  14. Jassim, S.A. y M.A. Naji. Novel antiviral agents: a medicinal plant perspective. J. Appl. Microbiol. 2003. 95: 412-27.
  15. Kimpton J. y M. Emerman. Detection of replication-competent and pseudotyped Human Immunodeficiency Virus with a sensitive cell line on the basis of activation of β-galactosidase gene. J. Virol. 1992. 66: 2232-2239.
  16. Klug,W., M. Cummings. Conceptos de Genética. Quinta edición. España: Prentice Hall. 1999.
  17. Lee-Huang S., P. Huang, P. Huang, A. Bouranbaiar, H. Chien y H. Kung. Inhibition of the integrase of Human Immunodeficiency Virus (HIV) type 1 by anti-HIV plan proteins MAP 30 and GAP 31. Proc. Natl. Acad. Sci. USA. 1995. 92: 8818-8822.
  18. Li B. Q, T. Fu, Y. Dongyan, J. A. Mikovits, F. W. Ruscetti y J. M. Wang. Flavonoid baicalin inhibits VIH-1 infection at the level of viral entry. Biochem. Biophys. Res. Commun. 2000. 276: 534-538.
  19. Lin Y., M. Y. Flavin, R. Schure, F. Chen, R. Sidwell, D. L. Barnard, J. H. Huffman y E. R. Kern. Antiviral Activities of Biflavonoids. Planta Med. 1999. 65: 120-125.
  20. Luciw, P. A. Human Immunodeficiency Viruses and their replication. En: Virology (eds. B.N. Fields, D.M. Knipe & P.M. Howley), Vol. Two. USA: Lippincott-Raven Publishers; 1996.
  21. MGT Inc. Sin fecha. Live Cell Luciferase Assay Kit. Product Information Sheet (0626-005).
  22. Mullin S.M., C. M. Jamjian, S. L. Spruance. Antiretroviral adverse effects and interactions: clinical recognition and management. En: The medical management of AIDS. (eds. M. A. Sande y P. A. Volderbing). USA: W.B. Saunders Company; 2000. 
  23. Nussbaum O., C. Broder y E. Berger. Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation. J. Virol. 1994. 68, 5411-5422.
  24. Oei S. L., J. Griesenbeck, M. Schweiger y M. Ziegler. Regulation of RNA polymerase II-dependent Transcription by Poly(ADP-ribosyl)ation of Transcription Factors. J. Biol. Chem. 1998. 273: 31644-31647.
  25. Ogata T., H. Higuchi, S. Mochida, H. Matsumoto, A. Kato, T. Endo, A. Kaji y H. Kaji. HIV-1 Reverse Transcriptase inhibitor from Phyllantus niruri. AIDS Res. Hum. Retroviruses. 1992. 8: 1937-1944.
  26. Pauwels R., J. Balzarini, M. Baba, R. Snoeck, D. Schols, P. Herdewijn, J. Desmyter y E. De Clerq. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. J. Virol. Methods. 1988. 20: 309-321.
  27. Pengsuparp, T. Specific inhibition oh Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Soulattrolide, a coumarin isolated from the latex of Calophyllum teysmannii. J. Nat. Prod. 1996. 59: 839-842.
  28. Peumans W., Q Hao y E. Van Damme. Ribosome-inactivating proteins from plants: more than RNA N-glycosidases? FASEB. 2001. 15: 1493-1505.
  29. Premanathan M., R. Arakaki, H. Izumi, K. Kathiresan, M. Nakano, N. Yamamoto, H. Nakashima. Antiviral properties of a mangrove plant, Rhizophora apiculata Blume, against Human Immunodeficiency Virus. Antiviral Res. 1999. 44: 113-122.
  30. Princen K y D. Schols. VIH chemokine receptor inhibitors as novel anti-VIH drugs. Cytokine Growth Factor Rev. 2005. 16: 659-677.
  31. Qian-Cutrone J., S. Huang, J. Trimble, H. L. Lin, M. Alam, S. E. Klohr y K. F. Kadow. Niruriside, a new HIV REV/RRE binding inhibitor from Phyllanthus niruri. J. Nat. Prod. 1996. 59: 196-199.
  32. Riss T. y R. Moravec. Improved Non-Radioactive Assay to Measure Cellular Proliferation or Toxicity: the Celltiter 96® AQueous One Solution Cell Proliferation Assay. Promega Notes Magazine. 1996. 59: 19-24.
  33. Schols D., M. Baba, R. Pauwels y E. De Clerq. Flow cytometric method to demonstrate whether anti-HIV agents inhibit virion binding to T4+ cells. J. Acquir. Immune Defic. Syndr. 1989. 2: 10-15.
  34. Sierra, S., B. Kupfer., R. Kaiser. Basics of the virology of HIV-1 and its replication. J. Clin. Virol. 2005. 34: 233-244.
  35. Tsai Y., T. Aoki, H. Maruta, H. Abe, H. Sakagami, T. Hatano, T. Okuda y S. Tanuma. Mouse Mammary Tumor Virus gene expression is supressed by oligomeric ellagitannins, novel inhibitors of poly (ADP ribose) glycohydrolase. J. Biol. Chem. 1992. 267: 14436-14442.
  36. Uchiumi F., H. Maruta, J. Inoue, T. Yamamoto y S. Tanuma. Inhibitory effect of tannic acid on Human Immunodeficiency Virus promoter induced by 12-O-tetra decanoylphorbol-13-acetate in Jurkat T-Cells. Biochem. Biophys. Res. Commun. 1996. 220: 411-417.
  37. Uchiumi F., T. Hatano, H. Ito, T. Yoshida y S. Tanuma. Transcriptional supresión of the HIV promoter by natural compounds. Antiviral Res. 2003. 58: 89-98.
  38. Wang Y., N. Neamati, J. Jacob, I. Palmer, S. Stahl, J. Kaufman, P. Huang, H. Winslow, Y. Pommier, P. Wingfield, S. Lee-Huang, A. Bax y D. Torchia. (1999). Solution structure of anti-HIV-1 and anti-tumor protein Map 30: structural insights into its multiple functions. Cell. 99: 433-442.
  39. Weiss, R.A. (2000). Getting to know HIV. Trop. Med. Int. Health. 5: 10-15.
  40. Xu H., F. Zeng, M. Wan y K. Sim. Anti-HIV triterpene acids from Geum japonicum .J. Nat. Prod. 1996. 59: 643-646.
  41. Zarocostas, J. (2005). Number of people infected with VIH worldwide reaches 40 m. Br. Med. J. 331: 1224.


Introducción
Mecanismos de replicación del VIH
Compuestos naturales de plantas con actividad anti-VIH
Otros inhibidores de la adsorción: el ácido repandusínico de Phyllanthus niruri.
Compuestos que actúan a nivel de la replicación intracelular
Conclusiones
Referencias

NOTA: Toda la información que se brinda en este artículo es de carácter investigativo y con fines académicos y de actualización para estudiantes y profesionales de la salud. En ningún caso es de carácter general ni sustituye el asesoramiento de un médico. Ante cualquier duda que pueda tener sobre su estado de salud, consulte con su médico o especialista.





Instituto de Medicina Tropical - Facultad de Medicina - Universidad Central de Venezuela.
Elaborado por el Centro de Análisis de Imágenes Biomédicas Computarizadas CAIBCO,
caibco@ucv.ve
Este portal ha sido desarrollado gracias al apoyo del Fonacit