1-Scotto J and Bailar JC III Rigoni-Stern and medical statistics: a nineteenth-century approach to cancer research. J Hist Med Allied Sci 1969, 24: 65-75.

2-García Tamayo J, Núñez Montiel JT. Identificación de partículas virales en el exudado vaginal de pacientes con papilomas y condilomas genitales. Resumen publicado en Patología (Mex)Supl 1-11,81, 1973.

3-Núñez Montiel JT, García Tamayo J. Colposcopia, histopatología y ultraestructura de papilomas y condilomas genitales. Resumen publicado en Patología(Mex) Supl 1-11, 86, 1973.

4-Meisels A, Fortín R. Condylomatous lesions of the cervix and vagina. Cytologic patterns. Acta Cytol 1976, 20: 505-509.

5-Puroloa E, Savia E. Cytology of gynecologic condyloma acuminatum. Acta Cytol 1977,21: 26-31.

6-García Tamayo J, Núñez Montiel JT. Investigación con el microscopio electrónico sobre la papilomatosis cérvico-vaginal. Acta Médica Venezolana (Ven) 1978, 25(3-4): 132-138.

7-Durst M et al. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 1983, 80: 3812-3815

8-Gissmann L et al. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci USA 1983, 80: 560-563

9- Boshart M et al. A new type of papillomavirus DNA is present in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J 1984, 3: 1151-1157

10-ZurHausen H. Virus in human cancers. Science 1991, 254:1167-1172

11- zur Hausen H Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002, 2: 342-350

12-Duensing S, Lee LY, Duensing A, Basile J, Piboonniyom S, Gonzalez S, Crum CP, Münger K. The human papillomavirus type 16E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Oncogene 2002; 21: 6241- 6248.

13-Duensing S, Münger K. The Human Papillomavirus Type 16 E6 and E7 Oncoproteins Independently Induce Numerical and Structural Chromosome Instability. Cancer Research 2002; 62: 7075-7082.

14-Munoz Nubia , Bosch X, de Sanjose S y col. Epidemiological classification of human papillomavirus types associated with cervical cancer. New Engl J Med 2003; 348: 518-527

15-Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, PetoJ, Meijer CJ, Muñoz N. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 1999; 189: 12-19.

16- Giannoudis A, Evans MF, Southern SA, Herrington CS. Basal keratinocyte tetrasomy in low-grade squamous intraepithelial lesions of the cervix is restricted to high and intermediate risk HPV infection but is not type-specific. Br J Cancer 2000, 82:424–428.

17- Southern SA, Evans MF, Herrington CS. Basal cell tetrasomy in low grade cervical squamous intraepithelial lesions infected with high risk human papillomaviruses. Cancer Res 1997,57:4210–4213.

18- Gius D, Funk MC, Chuang EY, Feng S, Huettner PC, Nguyen L, Bradbury CM, Mishra M, Gao S, Buttin BM, Cohn DE, Powell MA, Horowitz NS, Whitcomb BP, Rader JS.

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates.Cancer Research 2007, 67, 7113-7123.

19- zur Hausen H. Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix. Lancet 111: 955 957, 1994.

20- Molina J, Guzmán Bistoni C, Méndez V, Blasco-Olaetxea E, García Tamayo J. 2005. Alteraciones cromosómicas en el cáncer del cuello uterino.Vitae-Academia Biomédica Digital Octubre-diciembre 2005. http://caibco.ucv.ve/caibco/CAIBCO/Vitae/

21-Mitra AB, Murty VV, Li RG, Pratap M, Luthra UK, Chaganti RS. Allelotype análisis of cervical carcinoma. Cancer Res 1994, 54:4481- 4487.

22-Hapmton GM, Larson AA, Baergen rM, Sommers RL, Kern S, Cavanee WK. Simultaneous assesments of loss of heterocygozyty at multiple microsatellite loci using semiautomated fluorescent-based detection; subregional mapping of chromosomes 4 in cervical carcinoma. Proc Nat Acad Sci USA 1966, 93: 6704 – 6709.

23-Mullokandov MR, Kholodilov NG, Atkin NB, Burk RD, Johnson AB, Klinder HP. Genomic alterations in cervical carcinoma: losses of chromosomes heterozygocity and human papillomavirus tumor status. Cancer Res 1996, 56:197 – 205.

24-Kersemaekers AMF, Hermans J, Fleuren GJ, Van de Vijver MJ. Loss of heterocygocity for defined regions on chromosomes 3, 11 and 17 in carcinoma of the uterine cervix. Brit J Cancer 1998, 77: 192 – 200.

25-Kersemaekers AMF, van de Vijver MJ, Kenter GG, Fleuren GJ. Genetic Alterations During the Progression of Squamous Cell Carcinomas of the Uterine Cervix. Genes, Chromosomes & Cancer 1999, 26:346–354.

26- Bulten J, Poddighe PJ, Robben JC, Gemmink JH, de Wilde PC, Hanselaar AG:. Interphase cytogenetic analisis of cervical intraepithelial neoplasm. Am J Pathol 1998, 152: 325 – 327.

27- Mian C, Bancher D, Kohlberger P, Kainz C, Haitel A, Czerwenka K. Fluorescence in situ in cervical smears: detection of numerical aberrations of chromosomes 7, 3 and X and relationship to HPV infection. Gynecol Oncol 1999, 75: 41 – 46.

28- Bulten J, Melchers Willem JG, Kooy-Smits MM, De Wilde P, Poddighe PJ, Robben J, Mac Ville M, Massuger Leon FA, Nakkers J, Hanselaar AG. Numerical aberrations of chromosome 1 in cervical intraepithelial neoplasia are strongly associated with infection with high-risk human papillomavirus types. J Pathol 2002, 198: 300 – 309.

29-Sherwood JB, Shivapurkar N, Lin WM, Ashfaq R, Miller DS, Gazdar AF, Muller CY. Chromosome 4 Deletions Are Frequent in Invasive Cervical Cancer and Differ between Histologic Variants. 2000, 79: 90-96.

30- Hopman AH, Smedts F, Dignef W, Ummelen M, Sonke G, Mravunac M, Vooijs GP, Speel EJ, Ramaekers FC. Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J Pathol. 2004, 202:23-33.

31- Zhang A, Maner S, Betz R, Angstrom T, Stendahl U, Bergman F, Zetterberg A, Wallin KL. Genetic alterations in cervical carcinomas: frequent low-level amplifications of oncogenes are associated with human papillomavirus infection. Int J Cancer 2002, 101:427–433.

32- Heselmeyer K, Schröck E, du Manoir S, Blegen H, Shahs K, Steinbeck R, Auer G, Ried T. Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc. Natl. Acad. Sci. USA 1996,93: 479-484.

33-Ma YY, Wei SJ, Lin YC, Lung JC, Chang T-C, Whang-Peng J, Liu JM, Yang D-M, Yang WK, Shen CY. PIK3CA as an oncogene in cervical cancer. Oncogene 2000, 19: 2739-2744.

34-Olaharski AJ, Sotelo R, Solorza-Luna G, Gonsebatt ME, Guzman P, Mohar A, Eastmond DA.Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. Carcinogenesis 2005, 27: 337-343.

35-Krivak TC, McBroom JW, Seidman J, Venzon D, Crothers B, MacKoul PJ, Scott Rose G, Carlson JW, Birrer MJ. Abnormal Fragile Histidine Triad (FHIT) Expression in Advanced Cervical Carcinoma A Poor Prognostic Factor. Cancer Research 2001, 61: 4382-4385.

36-TakizawaS, NakagawaS, NakagawaK, YasugiT, FujiiT, KuguK, YanoT, YoshikawaH, TaketaniY. Abnormal Fhit expression is an independent poor prognostic factor for cervical cancer. British Journal of Cancer 2003,88:1213-1216.

37-Vecchione A, Zanesi N, Trombetta G, French D, Visca P, Pisan T, Botti C, Vecchione A, Croce CM, Manzini R. Cervical Dysplasia, Ploidy, and Human Papillomavirus Status Correlate with Loss of Fhit Expresión. Clinical Cancer Research 2001, 7: 1306-1312.

38- HidalgoA, Baudis M, Petersen I, Arreola H, Piña P, Vázquez-Ortiz G, Hernández D, González J, Lazos M, López R, Pérez C, García J, Vázquez K, Alatorre B, Salcedo M. Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma BMC Cancer. 2005, 77: 1471-2407

39-Pett MR, Alazawi WOF, Roberts I, Dowen S, Smith DI, Stanley MA, Coleman N. Acquisition of High-Level Chromosomal Instability Is Associated with Integration of Human Papillomavirus Type 16 in Cervical Keratinocytes. Cancer Research 2004, 64, 1359-1368.

40-Daksha Patel D,Angela Incassati A, Wang N, McCance DJ.Human Papillomavirus Type 16 E6 and E7 Cause Polyploidy in Human Keratinocytes and Up-Regulation of G2-M-Phase Proteins. Cancer Research 2004, 64: 1299-1306

41-Andrew J. Olaharski A, Sotelo R, Solorza-Luna G, Gonsebatt ME, Guzman P, Mohar A, Eastmond DA. Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. Carcinogenesis 2006, 27:337-343

42-Carlson JA, Healy K, Tran TA, Malfetano J, Wilson VL, Rohwedder A, Ross JF. Chromosome 17 Aneusomy Detected by Fluorescence in Situ Hybridization in Vulvar Squamous Cell Carcinomas and Synchronous Vulvar Skin. American Journal of Pathology. 2000, 157:973-983

43- Liu Y, Heilman SA, Illanes D, Sluder G, Chen JJ. p53-Independent Abrogation of a Postmitotic Checkpoint Contributes to Human Papillomavirus E6-Induced Polyploidy. Cancer Res 2007;67:2603–2610

44-Lengauer C, Kinzler KW,Vogelstein B. Genetic instabilities in human cancers. Nature 1998, 396, 643–649.

45-Duesberg P, Rausch C, Rasnick D, Hehlmann R. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc. Natl Acad. Sci. USA 1998, 95, 13692–13697.

46-Li R, Sonik A , Stindl R , Rasnick D, Duesberg P. Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. Proc. Natl Acad. Sci. USA 2000, 97, 3236–3241

47-MarzanoG, Corrado R, Merola C, Sbiroli F, Guadagni E, Vizza F, Del Nonno M, Carosi M,Galati M. Sperduti I. Analysis of chromosomes 3, 7, X and the EGFR gene in uterine cervical cancer progression. European Journal of Cancer 2004, 40: 1624 – 1629

48-Cortes-Gutierrez E, Davila-Rodriguez ML, Muraira-Rodriguez M,Said-Fernández S, Cerda-Flores RM. Association between the stages of cervical cancer and chromosome 1 aneusomy. Cancer genetics and cytogenetics 2005,159, 1: 44-47.

49 - Mullokandov NG. Y col. Genomic alterations in cervical carcinoma: Losses of chromosome Heterozygodsity and Human Papilloma Virus Tumor Status. Cancer Research 1996, 56: 197-205